Superoxide Dismutase (SOD)
Description:
The primary function of superoxide dismutase (SOD) is to specifically eliminate superoxide anions (O₂⁻) in the body, preventing oxidative damage to body components caused by these anions. SOD has a short half-life, typically only 6-10 minutes. Its large molecular weight makes it difficult to cross cell membranes, and oral administration is limited due to inactivation by proteases. Clinically, this limits its application. SOD is an acidic, relatively stable protein that is heat-resistant. It remains stable at pH 7.6-9 but is unstable below pH 6 and above pH 12, especially at pH 2 or lower. It is also resistant to hydrolysis by pepsin and trypsin.
Basic Information:
English Name: Superoxide Dismutase (SOD)
Aliases: Peroxidase
CAS Number: 9054-89-1
Source: Bovine or porcine blood
Molecular Weight: 32,000 - 34,000 Da
Activity: ≥2500 units/mg protein
Activity Definition: One unit will inhibit the reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25°C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per minute.
Appearance: Light blue powder, pinkish or off-white powder, or solid form.
Storage Conditions: -20℃
Applications:
Used in biochemical research, SOD is commonly applied clinically for the treatment of autoimmune diseases such as systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, scleroderma, autoimmune hemolytic anemia, and thrombocytopenia. It is also used in the treatment of certain cardiovascular diseases and for anti-aging purposes.