Uricase
Description:
Uricase, also known as uric acid oxidase, is an enzyme involved in the purine degradation pathway in living organisms. In birds, reptiles, and non-human primates, it catalyzes the oxidation of uric acid using molecular oxygen as an acceptor, producing allantoin, carbon dioxide, and hydrogen peroxide. Uricase was first discovered in the kidneys of cattle and has since been found in animals, plants, fungi, yeast, and bacteria.
Basic Information:
Chinese Name: 尿酸酶
Aliases: Urease, Uric Acid Oxidase
English Name: Uricase, Urate Oxidase
Molecular Weight: 3 kDa (SDS-PAGE)
Grade: BR
CAS Number: 9002-12-4
Isoelectric Point (pI): 5.4
Optimal pH: 8.5
Optimal Temperature: 45℃
Activity Definition: The amount of enzyme required to oxidize 1 µmol of uric acid per minute under conditions of pH 8.5 and 25℃
Storage Conditions: -20℃
Applications:
For research use, uricase catalyzes the rapid oxidation of uric acid to produce allantoin. It is commonly used to measure uric acid levels in serum and urine.